发明名称 |
Method for diagnosing efficacy of xenotypic antibody therapy |
摘要 |
<p>The invention provides methods for diagnosing the efficacy of a patient to xenotypic antibody therapy which include (1) measuring the level of an antibody produced by a patient that specifically binds to a xenotypic antibody after administration of the xenotypic antibody to the patient; (2) measuring the level of an anti-idiotype antibody produced by a patient that specifically binds to a xenotypic antibody after administration of the xenotypic antibody to the patient; (3) measuring the level of an antibody produced by a patient that specifically binds to a target antigen of a xenotypic antibody after administration af a xenotypic antibody to the patient; and (4) measuring the level of a T cell response produced by a patient to a target antigen of the xenotypic antibody after administration of a xenotypic antibody to the patient. In the methods of the invention, an increase in the level of antibody or T cell response produced by the patient after the administration of the xenotypic antibody relative to the level antibody or T cell response produced by the patient prior to the administration of the xenotypic antibody is indicative of a favorable diagnosis of efficacy.</p> |
申请公布号 |
EP1821104(A2) |
申请公布日期 |
2007.08.22 |
申请号 |
EP20070007737 |
申请日期 |
2001.02.08 |
申请人 |
ALTAREX MEDICAL CORPORATION |
发明人 |
NOUJAIM, ANTOINE |
分类号 |
G01N33/53;G01N33/68;A61K49/00;G01N33/569;G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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