PHARMACEUTICALLY ACTIVE PHOSPHATE BINDERS, THEIR MANUFACTURE, COMPOSITIONS CONTAINING THEM AND THEIR USE

摘要

A substance for use as a medicament, comprises a solid mixed metal compound of formula (I): Mll 1-a Mlll aObAn- c.zH2O (I) where Mll is at least one bivalent metal: Mlll bis at least one trivalent metal; An- is at least one n-valent anion; 2+a = 2b+Sigmacn; and Sigmacn < 0.9a. The substance may be made by heating at a temperature of from 200°C to 600°C, preferably from 250°C to 500°C of a substance comprising a compound of formula (II): Mll 1-xMlll x(OH)2An- y.mH2O (II) where Mll is at least one bivalent metal; Mlll is at least one trivalent metal; An- is at least one n-valent anion; x = Sigmayn 0 < x <= 0.5, 0 < y <= 1 and 0 <m <= 10.