| 摘要 |
<p>The present invention concerns a process for the manufacture of an adamantanamine of formula
wherein R, R' and X are as defined in the claims, which comprises
(i) reacting a compound of formula
with thiourea;
(ii) subjecting the resulting compound of formula
to an acid treatment and
(iii) isolating the resulting adamantanamine or a hydrohalogenide thereof. According to the process of the invention, valuable pharmaceuticals are obtainable, such as Memantine hydrochloride (R,R' = methyl), an uncompetitive NMDA( N -methyl-D-aspartate) receptor antagonist used as a new treatment for Alzheimer's disease, or Amantadine hydrochloride (R,R' = hydrogen) used as an antiviral or in the treatment of Parkinson's disease.</p> |
