发明名称 |
Cardiotrophin-1 compositions and methods for the treatment of tumor |
摘要 |
The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
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申请公布号 |
US7258983(B2) |
申请公布日期 |
2007.08.21 |
申请号 |
US20040895545 |
申请日期 |
2004.07.21 |
申请人 |
GENENTECH, INC. |
发明人 |
BOTSTEIN DAVID;GODDARD AUDREY;LAWRENCE DAVID A.;PENNICA DIANE;ROY MARGARET ANN;WOOD WILLIAM I. |
分类号 |
C12Q1/68;A61K38/00;C07H21/02;C07H21/04;C07K14/47;C07K14/52;C07K16/18;C07K16/24 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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