USE OF SODIUM CHANNEL BLOCKING COMPOUNDS AND ASPIRIN IN MANUFACTURING DRUGS FOR PRODUCING SYNERGISTICALLY ANALGESIC EFFECT IN MAMMALS

摘要

This invention relates to the use of combinations of a sodium channel blocki ng compound that binds to an SS1 or SS2 site of extracellular region of a sodiu m channel alpha subunit, and aspirin in manufacturing drugs for producing synergistically analgesic effect in mammals. Pharmaceutical compositions based upon this invention can enhance analgesic effect and reduce dosage of aspirin, therefore side effects and adverse reactions are decreased accordingly.