发明名称 APPLICATION OF RECEPTOR NK-1 ANTAGONISTS FOR TREATING CRANIOCEREBRAL AND SPINAL TRAUMAS OR NERVOUS TISSUE LESION
摘要 FIELD: chemico-pharmaceutical industry. ^ SUBSTANCE: the present innovation deals with applying receptor NK-1 antagonist, not obligatory in combination with magnesium salt, for treating and/or preventing craniocerebral and spinal trauma or nervous tissue lesion, where receptor NK-1 antagonist is being a compound of general formula , where R, R1, R2, R2', R3, R4 have values mentioned in the description of the present innovation, its pharmaceutically acceptable acid-additive salts, either separately or in combination with magnesium salt. The example is the application of 2-(3.5-bis-trifluoromethylphenyl)-N-methyl-N-(6-morpholine-4-yl-4-ortho-tolylpyridine-3-yl)isobutyramide. ^ EFFECT: higher efficiency of therapy. ^ 8 cl, 3 dwg
申请公布号 RU2304435(C2) 申请公布日期 2007.08.20
申请号 RU20040102397 申请日期 2002.07.03
申请人 F.KHOFFMANN-LJA ROSH AG 发明人 KHOFFMANN TORSTEN;NIMMO ALAN DZHON;SLEJT EHNDR'JU;VANKAN P'ER;VINK ROBERT
分类号 A61K31/4427;C07D213/74;A61K31/435;A61K31/4418;A61K31/4436;A61K31/4439;A61K31/444;A61K31/4545;A61K31/496;A61K31/506;A61K31/5355;A61K31/5377;A61K31/541;A61K39/395;A61P1/04;A61P1/08;A61P11/06;A61P25/00;A61P25/04;A61P25/06;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/36;A61P27/02;A61P27/16;A61P29/00;A61P37/08;A61P43/00;C07D213/75;C07D213/82;C07D401/04;C07D401/12;C07D409/04;C07D413/04;C07D413/12 主分类号 A61K31/4427
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