| 摘要 |
<p>To provide a method for producing a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound simply, safely and in good yield, whereby drawbacks of prior art have been solved. A method for producing a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound of the formula (2):
wherein each of R 1 and R 2 which are independent of each other, is a hydrogen atom, an alkyl group or a cycloalkyl group, each of R 3 and R 4 which are independent of each other, is a hydrogen atom or an alkyl group, provided that R 1 and R 2 , or R 2 and R 3 , may be bonded to each other to form a cycloalkyl group together with the carbon atoms to which they are bonded, and X 2 is a halogen or an anionic residue derived from an acid, which comprises reacting a 3-halogeno-4,5-dihydroisoxazole compound of the formula (1) :
wherein R 1 , R 2 , R 3 and R 4 are as defined above, and X 1 is a halogen, with thiourea in the presence of an acid.</p> |
