| 摘要 |
The invention is related to compounds of formula (I) that can be used as antagonists of the TGFß family type I receptors, Alk5 and/or Alk4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFß family signaling activity is desirable. |
| 申请人 |
BIOGEN IDEC MA INC;LEE, WEN-CHERNG;CHUAQUI, CLAUDIO;SUN, LIHONG;HOEMANN, MICHAEL;NIU, DEQIANG;YAN, DINGXUE;PETTER, RUSSELL, C.;FENG, HELEN (XIAOMEI) |
发明人 |
LEE, WEN-CHERNG;CHUAQUI, CLAUDIO;SUN, LIHONG;HOEMANN, MICHAEL;NIU, DEQIANG;YAN, DINGXUE;PETTER, RUSSELL, C.;FENG, HELEN (XIAOMEI) |
