PEPTIDE DOMAIN REQUIRED FOR INTERACTION BETWEEN THE ENVELOPE OF A VIRUS PERTAINING TO THE HERV-W INTERFERENCE GROUP AND AN HASCT RECEPTOR

摘要

The invention relates to a peptide domain required for interaction between the envelope of a virus pertaining to the HERV-W interference group and an hASCT receptor, comprising an N end point and a C end point. Said peptide domain is defined, at the N end point thereof, by a pattern formed by the amino acids L (Z)_a-proline-cysteine-X-cysteine in which Z is any amino acid, a is a whole number between 2 and 30, and X is any amino acid, and at the C end point thereof, by a pattern formed by the amino acids serine-aspartic acid-X_a-X_b-X_c-X_d-X_e-aspartic acid-X_f X_g-(Z)_ß in which X_a, X_b, X_c, X_d, X_e, X_f X_g are any amino acids, Z is any amino acid, ß is a whole number between 15 and 25, preferably 20. The peptide domain comprises, between the N end point and the C end point , at least one pattern selected from the following patterns: a pattern formed by the amino acids cysteine-tyrosine-X₂-X₃-X₄-X₅- X₆-cysteine in which X₂, X₃, X₄, X₅, X₆ are any amino acids, and a pattern formed by the amino acids cysteine-X₇-X₈-X₉-X₁₀-X₁₁- X₁₂- X₁₃-X₁₄-X₁₅-cysteine-trytophane in which X₇, X₈, X₉, X₁₀, X₁₁, X₁₂, X₁₃, X₁₄, X₁₅ are any amino acids.