ENZYME INHIBITORS

摘要

Compounds of of formula (I), are aurora kinase inhibitors:wherein X is -N-, -CH₂-N-, -CH₂-CH-, or -CH-; R₁ is a radical of formula (IA) wherein Z is -CH₂-, -NH-, -0-, -S(O)- -S-, -S(O)₂ or a divalent monocyclic carbocyclic or heterocyclic radical having 3-7 ring atoms; Alk is an optionally substituted divalent C₁-C₆ alkylene radical; A is hydrogen or an optionally substituted monocyclic carbocyclic or heterocyclic ring having 5-7 ring atoms; r, s and t are independently 0 or 1, provided that when A is hydrogen then at least one of r and s is 1; R₂ is halogen, -CN, -CF₃, -OCH₃, or cyclopropyl; and R₃ is a radical of formula (IB) wherein Q is hydrogen or an optionally substituted phenyl or monocyclic heterocyclic ring with 5 or 6 ring atoms; Z¹ is -S-, -S(O)-, -S(O)₂-, -O-, -SO₂NH-, -NHSO₂-, NHC(=O)NH, -NH(C=S)NH-, Or -N(R₄)- wherein R₄ is hydrogen, C₁-C₃ alkyl, cycloalkyl, or benzyl; and Alk¹ and Alk² are, independently, optionally substituted divalent C₁-C₃ alkylene radicals; and m, n and p are independently 0 or 1.