PREPARATION AND COMPOSITION OF A SOLID DOSAGE FORM CONTAINING TACROLIMUS AND/OR SIROLIMUS

摘要

A method is provided for preparing a solid dosage form comprising a water-insoluble medicinally active substance selected from tacrolimus and sirolimus, whereby the medicinally active substance is dissolved in an organic solvent, a mixture comprising at least one pharmaceutically acceptable carrier with swelling ability is then coated with the solvent containing the medicinally active substance, the solvent is evaporated, and the mixture is processed into a suitable solid dosage form.