Variant Neublastin polypeptides having substitutions at selected amino acid residues are disclosed. Substitution at one or more selected amino acid residues decreases heparin binding and increases serum exposure of variant Neublastin polypeptides. Also disclosed are methods of using variant Neublastin polypeptides to treat disorders and activate the RET receptor in a mammal.
申请公布号
WO2006023781(A3)
申请公布日期
2007.08.16
申请号
WO2005US29637
申请日期
2005.08.18
申请人
BIOGEN IDEC MA INC.;ROSSOMANDO, ANTHONY;SILVIAN, LAURA;PEPINSKY, R., BLAKE
发明人
ROSSOMANDO, ANTHONY;SILVIAN, LAURA;PEPINSKY, R., BLAKE