METHOD OR AGENT FOR INHIBITING THE FUNCTION OF EFFLUX PUMP OF PSEUDOMONAS AERUGINOSA

摘要

Disclosed is a method or agent for inhibiting the function of an efflux pump of Pseudomonas aeruginosa with good efficiency. The method comprises modifying any amino acid residue selected from 100^th to 109^th amino acid residues and 311^th to 320^th amino acid residues in an amino acid sequence for mature OprM protein. Also disclosed is an agent having an activity of the inhibition mentioned above. Further disclosed is a method for screening of the agent.