| 摘要 |
<p>The invention relates to a radiation treatment apparatus and an inverse treatment planning method for intensity modulated particle therapy for the treatment of a target within a bio logical system using at least two fields, each field comprising a plurality of Bragg peaks, the at least two fields being planned to place a defined number of beam spots j from different directions with certain weights w<SUB>j</SUB> within the target. The inverse treatment planning method optimizes the weights w<SUB>j</SUB> o f the beam spots for the at least two fields simultaneously in order to produce a prescribed biological effect within the target by minimizing an objective function based on biological effects e, the biological effects e being treated in a linear-quadratic model, which describes the biological effects in the target by two parameters a and ß, where e = aD + ßD<SUP>2</SUP>, D denoting a dose, and wherein the two parameters a and ß for each voxel i of the target (a<SUB>i</SUB> and ß<SUB>i</SUB>) are calculated as dose-averaged mean values of a<SUB>i,j</SUB>- and vß<SUB>i , j</SUB> -components, which relate to all beam spots j contributing to a total dose D<SUB>i</SUB> in the voxel i.</p> |
