摘要 |
A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase. |
申请人 |
MEDICAGO INC.;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE DE ROUEN |
发明人 |
PACCALET, THOMAS;BARDOR, MURIEL;RIHOUEY, CHRISTOPHE;GOMORD, VERONIQUE;FAYE, LOIC;LEROUGE, PATRICE;AQUIN, STEPHANIE;VEZINA, LOUIS-PHILIPPE;D'AOUST, MARC-ANDRE |