NITROOXY-COMPRISING DERIVATIVES OF APRACLONIDINE AND BRIMODNIDINE AS AL PHA2 -ADRENERGIC RECEPTOR AGONISTS
摘要
<p>The present invention relates to alpha<SUB>2</SUB>-adrenergic receptor agonist nitrooxyderivatives of formula (I), wherein A is selected from (Ia) or (Ib) having improved pharmacological activity and enhanced tolerability. They can be employed for the treatment of ocular diseases, in particular high intraocular pressure and glaucoma. A-X<SUB>1</SUB>-Y-ONO<SUB>2</SUB> (I)</p>
申请公布号
WO2007090793(A1)
申请公布日期
2007.08.16
申请号
WO2007EP51017
申请日期
2007.02.02
申请人
NICOX S.A.;PFIZER INC.;BENEDINI, FRANCESCA;IMPAGNATIELLO, FRANCESCO;BIONDI, STEFANO;ONGINI, ENNIO;CHONG, WESLEY KWAN MUNG
发明人
BENEDINI, FRANCESCA;IMPAGNATIELLO, FRANCESCO;BIONDI, STEFANO;ONGINI, ENNIO;CHONG, WESLEY KWAN MUNG
