发明名称 |
Novel process for the preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(-methoxyphenoxy)-ethyl] amino]-propan-2-ol |
摘要 |
The present invention discloses a novel process for preparation of carvedilol by using eco friendly solvents to obtain the said carvedilol in high purity. The said process comprises, reacting 4-hydroxy carbazole of formula (IV) with epichlorhydrin in presence of an organic solvent and a base at temperatures between 10° C.-30° C.; further reacting the resultant 4-(2,3-epoxypropoxy)- carbazole of formula (II) with a salt of 2-(2-methoxyphenoxy)ethylamine of formula (III), preferably hydrochloride salt in presence of a base and a hydroxylic solvent at temperatures between 30° C.-90° C.
|
申请公布号 |
US2007191456(A1) |
申请公布日期 |
2007.08.16 |
申请号 |
US20050568732 |
申请日期 |
2005.05.03 |
申请人 |
TARUR VENKATASUBRAMANIAN R;SATHE DHANANJAY G;KULKARNI SWAPNIL J |
发明人 |
TARUR VENKATASUBRAMANIAN R.;SATHE DHANANJAY G.;KULKARNI SWAPNIL J. |
分类号 |
A61K31/403;C07D209/00;C07D209/82;C07D209/88;C07D405/12 |
主分类号 |
A61K31/403 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|