发明名称 |
Il-11 muteins |
摘要 |
The present invention relates to new IL-11 muteins of which site I hydrophobocity has been increased. These muteins act as IL-11 agonist or hyperagonist, and are notably useful as anti-thrombocytopenia agents, and as agents improving the resistance of an organism to the deleterious in vivo effects induced by radiation or chemotherapy during the treatment of cancer or for the preparation of patient to transplantation.
|
申请公布号 |
US2007190024(A1) |
申请公布日期 |
2007.08.16 |
申请号 |
US20040565626 |
申请日期 |
2004.07.29 |
申请人 |
INSERM INSTITUT NATIONAL DE LA SANTE ET DE LA RECH |
发明人 |
PARIS FRANCOIS E.;JACQUES YANNICK;CONTENT JEAN;WANG XIAO-MING;HARMEGNIES DIMITRI;GROTZINGER JOACHIM |
分类号 |
A61K38/20;A61K48/00;C07H21/04;C07K14/54;C12P21/04 |
主分类号 |
A61K38/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|