发明名称 |
INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF |
摘要 |
The present invention relates to a production method of an optically active morpholine compound represented by the formula 10, which includes the following steps: wherein each symbol is as defined in the specification. The present invention also relates to a production method of an compound represented by the formula 55, which includes the following steps: wherein each symbol is as defined in the specification. According to the production method of the present invention, an optically active 2-aryl-substituted morpholine compound and 3-oxo-3-(pyrimidin-4-yl)propionate, which are important as starting materials for synthesizing 2-(2-arylmorpholin-4-yl)-1-methyl-1H-[4,4']bipyrimidinyl-6-one having a tau protein kinase 1 inhibitory activity and useful as a therapeutic drug for Alzheimer's disease and the like, can be produced in a high yield by an industrially advantageous method. |
申请公布号 |
WO2007011065(A3) |
申请公布日期 |
2007.08.16 |
申请号 |
WO2006JP314932 |
申请日期 |
2006.07.21 |
申请人 |
MITSUBISHI PHARMA CORPORATION;SANOFI-AVENTIS;OKUYAMA, MASAHIRO;UEHARA, FUMIAKI;IWAMURA, HIROSHI;WATANABE, KAZUTOSHI |
发明人 |
OKUYAMA, MASAHIRO;UEHARA, FUMIAKI;IWAMURA, HIROSHI;WATANABE, KAZUTOSHI |
分类号 |
C07D265/30;C07D265/32 |
主分类号 |
C07D265/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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