BINDING INHIBITOR OF SPHINGOSINE-1-PHOSPHATE

摘要

It is intended to provide a compound useful as a drug which has an effect of inhibiting the binding of S1P to its receptor Edg-1(S1P<SUB>1</SUB>). A compound represented by the following formula (I): [Chemical formula 1] wherein Ar represents a monocyclic heterocycle having 1 or 2 nitrogen atoms; A represents oxygen, etc.; Y<SUP>1</SUP>, Y<SUP>2</SUP> and Y<SUP>3</SUP> independently represent each carbon or nitrogen; R<SUP>1</SUP> represents hydrogen, C<SUB>1-6</SUB> alkyl, etc.; R<SUP>2</SUP> represents C<SUB>1-6</SUB> alkyl, C<SUB>3-8</SUB> cycloalkyl, etc.; R<SUP>3</SUP> represents C<SUB>1-18</SUB> alkyl, etc.; R<SUP>4 </SUP>represents hydrogen or C<SUB>1-6</SUB> alkyl; and R<SUP>5</SUP> represents C<SUB>1-10</SUB> alkyl, etc.; or a pharmaceutically acceptable salt thereof.