NOVEL AMIDOPROPIONIC ACID DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME

摘要

Disclosed is a compound having S1P receptor antagonist activity, which is useful as an immunosuppressive agent. The compound has few side effects, and is orally administrable. Specifically disclosed are a compound represented by the general formula (I) below, a salt thereof, a solvate of any of them, and a pharmaceutical product containing any of them. (I) (In the formula, V represents -NH-CO- or -CO-NH-; A represents -COOR<SUP>7</SUP> (wherein R<SUP>7</SUP> represents a hydrogen atom or an alkyl group) or the like; R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP> and R<SUP>4</SUP> independently represent a hydrogen atom, a hydroxyl group, an amino group or an alkyl group; R<SUP>5</SUP> and R<SUP>6</SUP> independently represent a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group; Q represents -CH<SUB>2</SUB>O-, -CH<SUB>2</SUB>-CH<SUB>2</SUB>-, -CH=CH-, -CH<SUB>2</SUB>-O-N=CR<SUP>8</SUP>-, -CONR<SUP>9</SUP>-, -NR<SUP>10</SUP>CO-, -CH<SUB>2</SUB>NR<SUP>11</SUP>CO- or -CH<SUB>2</SUB>CH<SUB>2</SUB>NR<SUP>12</SUP>CO-; and Y and Z respectively represent a benzene or a group composed of an aromatic heterocyclic ring.)