摘要 |
This invention provides a method of treating a patient suffering from a tumor overexpressing N-CoR comprising administering to the patient a phosphatase ligand, alone or in combination with "a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N-CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N- CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N-CoR. This invention also provides a method of assessing the- likelihood that a patient is suffering from a tumor overexpressing N-CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N-CoR has suffered a recurrence of a tumor overexpressing N-CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme. |
申请人 |
LIXTE BIOTECHNOLOGY HOLDINGS, INC.;THE GOVERMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES |
发明人 |
ZHUANG, ZHENGPING;OLDFIELD, EDWARD, H.;PARK, DERIC, M.;LUBENSKY, IRINA;LI, JIE;KOVACH, JOHN, S. |