| 摘要 |
<p>Compounds of the general formula <FORM:1104292/C2/1> (wherein A and A1 are alkyl groups each having 2 or 3 carbon atoms, R1 is a hydrogen atom, R is a methyl or ethyl group and A, A1 and R have between them from 5 to 7 carbon atoms, or A and A1 are alkyl groups each having 1 to 3 carbon atoms and R and R1 are each a methyl group) and their acid addition salts are prepared by (a) catalytically hydrogenating an acid addition salt of a secondary ketoamine of the formula <FORM:1104292/C2/2> optionally followed by conversion to the free base or another acid addition salt, or (b)-in the case of compounds in which R1 is a hydrogen atom-reacting a primary amine of the formula <FORM:1104292/C2/3> with CH3COR and catalytically hydrogenating the product, optionally followed by conversion to an acid addition salt. The starting materials for process (a) may be prepared by reacting a haloketone of the formula <FORM:1104292/C2/4> (wherein X is a halogen atom) with RR1CH3CNH2 in the presence of a solvent and converting the product to an acid addition salt. The preparation of p-dipropoxybenzene, 2,5-dipropoxypropiophenone, 2,5 - dipropoxyisonitrosopropiophenone and racemic erythro - a - (2,5 - dipropoxyphenyl) - b - aminopropanol and its hydrochloride is described. The compounds of the invention have anti-arrhythmic activity, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.</p> |
