| 摘要 |
This application relates to 3-substituted and 4-substituted cis-diols. Specifically, there are provided 3-substituted diols of formula (II) and 4-substituted cis-diols having (1S, 2R) and (1R, 2S) absolute configurations of formulae (III) and (IV). Also provided are processes for making such 3- and 4-substituted cis-diols using a reductive fission reactio n. The compounds described herein are useful as synthons for the preparation of various compounds including therapeutics, agricultural, polymers and other classes of compounds. In formulae (II, III and IV), R is halogen, CN, aryl, alkyl, alkenyl, alkynyl, O-alkyl, CF3 or NO 2.
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