发明名称 |
Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof |
摘要 |
The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula I: wherein Ar and R<SUB>6</SUB>-R<SUB>10 </SUB>are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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申请公布号 |
US7256219(B2) |
申请公布日期 |
2007.08.14 |
申请号 |
US20030471720 |
申请日期 |
2003.10.16 |
申请人 |
CYTOVIA, INC. |
发明人 |
CAI SUI XIONG;REDDY P. SANJEEVA;DREWE JOHN A.;NGUYEN BAO NGOC;KASIBHATLA SHAILAJA |
分类号 |
A61K31/12;A61K31/34;A61K31/40;A61K31/47;A61K45/06;A61P31/04;A61P43/00;C07C45/74;C07C49/00;C07C49/84;C07C205/45;C07D207/18;C07D209/04;C07D213/50;C07D221/02;C07D307/02;C07D333/00 |
主分类号 |
A61K31/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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