| 摘要 |
A local system for the release of active principle is described which consis ts of approximately spherical or rotation symmetrical bodies which are composed essentially of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxid e or barium sulphate and one or more pharmaceutical active principles, in particular antibiotics, and which are produced by radical polymerisation, radical polymerisation activators effective in the temperature range of 10-80 .degree.C or residues of these polymerisation activators from the groups of aromatic amines, heavy metal salts and barbiturates not being contained therein. A process for the production of the local system for the release of active principle in the case of which a) a paste is produced by mixing methyl methacrylate, polymethyl methacrylat e or poly-methyl methacrylate co-methyl acrylate, zirconium dioxide and/or barium sulphate, o ne or more pharmaceutical active principles and a thermally decomposing radical initiator, the paste having a viscosity such that it cannot be deformed at room temperature by the effect of gravity; b) the paste is injection moulded by an injection moulding device without heating at room temperature into approximately spherical or rotation-symmetrical bodies or t he approximately spherical or rotation symmetrical bodies are injection-moulded onto a wire; c) the bodies are heated to a temperature at which the polymerisation initiator decomposes.
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