IMPROVEMENT OF LEVELS AND/OR SUSTAINABILITY OF DNA-BASED GENE EXPRESSION
摘要
<p>The invention encompasses methods for improving the level and/or suslainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to introduce or to comprise signals that limit or constrain the positions of nucleosome cores, and (b) introducing the modified target nucleic acid into the eukaryotic cell, wherein the modified target nucleic acid has improved levels and/ or sustainability of expression compared to original unmodified nucleic acid.</p>
申请公布号
WO2007089732(A2)
申请公布日期
2007.08.09
申请号
WO2007US02453
申请日期
2007.01.29
申请人
CARNEGIE INSTITUTION OF WASHINGTON;STANFORD UNIVERSITY;FIRE, ANDREW;GRACEY, LIA;LUI, WENG, ONN