The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either(R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.
申请公布号
WO2007090071(A2)
申请公布日期
2007.08.09
申请号
WO2007US61183
申请日期
2007.01.27
申请人
ISIS PHARMACEUTICALS, INC.;SWAYZE, ERIC, E.;SETH, PUNIT, P.