| 摘要 |
PROBLEM TO BE SOLVED: To provide a quick disintegrating tablet which contains an active ingredient and compounding agents in a devised combination, has good mixture powder flowability and good outflow property from the hopper of a tableting machine, does not cause a capping phenomenon, before tableted, has a reduced tablet weight variation, maintains good tablet disintegrability, and has practical tablet hardness, and to provide a production method by a dry direct tableting method. SOLUTION: This dry directly tableted quick-disintegrating tablet is characterized by comprising (a) an active ingredient, (b) at least one selected from the group consisting of acids selected from citric acid, tartaric acid, malic acid, lactic acid, and ascorbic acid or their alkali metal salts; alkali metal bicarbonates; and alkali metal carbonates, as a solubilizer, (c) a vehicle, (d) a binder, (e) a disintegrant, (f) a fluidizing agent, and (g) a combination of magnesium stearate with a sugar fatty acid ester as a lubricant. COPYRIGHT: (C)2007,JPO&INPIT
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