PEM-3-LIKE POLYPEPTIDES, COMPLEXES, AND RELATED METHODS

摘要

The present disclosure relates to the discovery that PEM-3-LIKE (also known as RKHD2) interacts with three polypeptides: p32, FNBP3 and PCBP1 . Given that PEM-3-LIKE participates in viral replication, the polypeptide complexes and methods disclosed herein may, for example, be used in the identification of antiviral agents. The present disclosure also relates to novel compositions and methods for treating HIV infection. The disclosure relates to the discovery that reduced expression of p32 or PEM-3-LIKE results in decreased expression of the HIV-1 structural protein GAG.