COMPOSITIONS AND METHODS FOR TREATING COGNITIVE DISORDERS

摘要

The present invention relates to the use of inhibitors or blockers of I_h (hyperpolarization-activated cationic current) channels in the treatment of cognitive disorders. In preferred aspects of the present invention, an effective amount of a compound is administered to a patient in need, wherein the compound has the chemical structure: Where R₁ is H, or an optionally substituted C₁-C₃ alkyl, preferably a C₂ alkyl (ethyl) group; R² is an optionally substituted C₁-C₃ alkyl group, preferably a methyl group; R³ is H, an optionally substitutedC₁-C₃ alkyl (preferably methyl), a halogen or 0(Ci-Ca) alkyl; R⁴ is an optionally substituted C₁-C₆ alkyl, C(O)-(C₁-C₅)alkyl, C(O)-aryl, C(O)O-(C₁- C₄)alkyl, C(O)O-aryl, or an optionally substituted heterocyclic, aryl or heteroaryl group; R⁴ais H or an optionally substituted C₁-C₆ (preferably a C₁-C₃) alkyl; R⁵, R⁶ and R⁷ are each independently H, halogen, an optionally substituted C₁-C₆ alkyl (preferably, an optionally substituted C₁-C₃ alkyl), 0-(C₁-C₃) alkyl, or an optionally substituted heterocyclic, aryl or heteroaryl group; Y^- is an anion of a pharmaceutically acceptable salt (a physiologically acceptable anion, preferably a Cl^-, Br^-, I^-, OAc^-); or a solvate or polymorph thereof, optionally, in combination with guanfacine and/or chelerythrine, and a pharmaceutically acceptable carrier, additive or excipient to a patient in need of therapy.