发明名称 |
MGRA IS A REDOX REGULATOR OF ANTIBIOTIC SENSITIVITY AND VIRULENCE |
摘要 |
The present invention relates to the identification of a specific cysteine (Cys) residue in MgrA of Staphylococcus aureus and homologs in other bacteria that acts as a redox switch to regulate virulence of S. aureus and expression of bacterial genes that confer resistance to antibiotics. In addition, MgrA is found to be a key virulence determinant for S. aureus. Oxidative regulation of other Cys containing proteins in various bacteria has been observed, leading to the ability to modulate virulence and resistance of these organisms. |
申请公布号 |
WO2007090123(A2) |
申请公布日期 |
2007.08.09 |
申请号 |
WO2007US61316 |
申请日期 |
2007.01.30 |
申请人 |
UNIVERSITY OF CHICAGO;CHEN, PENG;HE, CHUAN |
发明人 |
CHEN, PENG;HE, CHUAN |
分类号 |
C12Q1/18;A61P31/04;C07K14/195 |
主分类号 |
C12Q1/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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