发明名称 |
Filoviral immunosuppressive peptides and uses thereof |
摘要 |
The invention provides a region of strong secondary structure conservation between the C-terminus domain of the envelope glycoprotein of filoviruses and an immunosuppressive domain found in retroviral envelope glycoproteins. The invention provides filoviral peptides and modified derivatives thereof with strong immunosuppressive bioactivity. The invention further provides methods for treatment of autoimmune disorders by administering the immunosuppressive peptide. The invention also provides methods for the identification of therapeutic agents that modulate the immunosuppressive activity of the peptides. Antibodies against the inventive peptides and the modified derivatives thereof are also provided. Furthermore, the invention provides methods for treatment of filoviral infection by administering compositions comprising the antibodies and/or the therapeutic agents that modulate the immunosuppressive activity of the inventive peptides.
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申请公布号 |
US2007185025(A1) |
申请公布日期 |
2007.08.09 |
申请号 |
US20060518641 |
申请日期 |
2006.09.11 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
PALACIOS GUSTAVO;YADDANAPUDI KAVITHA;LIPKIN W. I. |
分类号 |
A61K38/17;A61K38/10;C07K7/08;C07K14/82;G01N33/574 |
主分类号 |
A61K38/17 |
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