发明名称 |
ENHANCER-CONTAINING GENE TRAP VECTORS FOR RANDOM AND TARGETED GENE TRAPPING |
摘要 |
<p>The present invention relates to a novel class of gene trap vector (enhanced gene trap vectors, eGTV) for efficiently identifying silent or weakly expressed target genes in mammalian genomes, methods of their production and methods for identifying and mutating target genes by using the enhanced gene trap vectors. The gene trap vectors of the present invention can also be used for inducing the expression of silent genes and enhancing the expression of weakly expressed genes. The use of the enhanced gene trap vectors for creating transgenic organisms to identify gene function and to validate pharmaceutical compounds prior to clinical applications is a further aspect of the present invention.</p> |
申请公布号 |
EP1815000(A1) |
申请公布日期 |
2007.08.08 |
申请号 |
EP20050813516 |
申请日期 |
2005.11.28 |
申请人 |
FRANKGEN BIOTECHNOLOGIE AG;GSF-FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT,GMBH;MPG MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
VON MELCHNER, HARALD;SCHNUETGEN, FRANK;WURST, WOLFGANG;RUIZ, PATRICIA |
分类号 |
C12N15/867;C12N15/10;C12N15/85 |
主分类号 |
C12N15/867 |
代理机构 |
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代理人 |
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地址 |
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