METHOD OF DIAGNOSIS/PROGNOSIS OF HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA COMPRISING THE PROFILING OF LPL/ADAM GENES

摘要

The present invention provides methods of diagnosis and prognosis of human chronic lymphocytic leukemia (CLL) in a patient in need thereof and methods to determine IgVHmutational status. The methods of the present invention involve measuring the expression profile of two known genes: LPL and ADAM29; and comparing the ratio of their expression to diagnose the presence of CLL or to prognose the likelihood of developing CLL or the symptoms consistent with CLL.