Hybrid cells obtainable from antigen presenting cells

摘要

A rapid, simple-to-use method for preparing hybrid cells, applicable to fully differentiate, non-dividing cells, entails bringing at least two different cells into contact under conditions that promote cell fusion and then purifying the resultant hybrid without antibiotic or metabolic selection. This approach yields hybrid cells useful in a variety of applications, including clinical treatment regimens, as cellular modulators of the immune system. For instance, dendritomas produced by fusing dendritic cells with cancer cells may be used as a cellular vaccine.