发明名称 |
Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis |
摘要 |
The present invention relates to the treatment of coronary heart disease by revascularization therapy, and more particularly to the intramyocardial injection of a pharmaceutical composition comprising a recombinant fibroblast growth factor-1 protein or a fragment of a recombinant fibroblast growth factor-1 protein, optionally, with a physiologic glue for inducing local neoangiogenesis in ischemic myocardium. Methods of producing the recombinant fibroblast growth factor 1 protein and fragments are also disclosed.
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申请公布号 |
US7252818(B2) |
申请公布日期 |
2007.08.07 |
申请号 |
US20030649480 |
申请日期 |
2003.08.27 |
申请人 |
CARDIOVASCULAR BIOTHERAPEUTICS, INC. |
发明人 |
STEGMANN THOMAS J. |
分类号 |
A61K38/18;C07K14/50;C12N1/21;C12N15/70 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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