SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4- (2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS.

摘要

Disclosed herein are methods for synthesizing N-(4-fluorobenzyl -N-(I-methylpiperidin i)4-yl)-N'-(442-methylpropyloxy)-phenylmethyl)carbamide,Formula (I). Also disclosed herein is the hemi itartrate salt of N-(4- fluorobenzyl)-N-(I-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) iphenylmethyl)carbamideand methods for obtaining the salt. Further disclosed are various crystallineforms of N-(4-fluorobenzyl)-N-(I-methylpiperidin-4-yl)-N'-(4-(2- metylpropyloxy)-phenymethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.