发明名称 |
Enzymatic production of Glycolic acid |
摘要 |
Various methods are provided for the enzymatic production of glycolic acid from glycolonitrile. These methods include: 1) use of Acidovorax facilis 72W nitrilase mutants having improved nitrilase activity for converting glycolonitrile to glycolic acid, and 2) methods to improve catalyst stability and/or productivity. The methods to improve catalyst stability/productivity include use of reaction stabilizers, running the reactions under substantially oxygen free conditions, and controlling the concentration of substrate in the reaction mixture.
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申请公布号 |
US2007178556(A1) |
申请公布日期 |
2007.08.02 |
申请号 |
US20070712336 |
申请日期 |
2007.02.28 |
申请人 |
DICOSIMO ROBERT;PAYNE MARK S;PANOVA ANNA;THOMPSON JEFFERY S;O'KEEFE DANIEL P |
发明人 |
DICOSIMO ROBERT;PAYNE MARK S.;PANOVA ANNA;THOMPSON JEFFERY S.;O'KEEFE DANIEL P. |
分类号 |
C12P21/06;C07H21/04;C12N1/21;C12N9/80;C12N15/74 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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