Pyrazolopyrimidine compounds and their use in medicine

摘要

Compounds of formula (I) or salts, N-oxides, hydrates or solvates thereof are inhibitors of kinase activity, and useful for the treatment of, for example, cancer, psoriasis or restenosis: wherein ring A is an optionally substituted carbocyclic or heterocyclic radical. Alk represents an optionally substituted divalent C1-C₆ alkylene radical. n is 0 or 1. Q represents a radical of formula -(Alk¹)_p (X)_r-(Alk²)_s-Z wherein in any compatible combination Z is hydrogen or an optionally substituted carbocyclic or heterocyclic ring; Alk¹ and Alk² are optionally substituted divalent C₁-C₆ alkylene radicals which may contain a -O-, -S- or -NR^A- link, wherein R^A is hydrogen or C₁-C₆ alkyl; X represents -O-, -S-, -(C-O)-, -(C-S)-, -SO₂-, -SO-, -C(-O)O-, -OC(-O)-, -C(-O)NR^{A-, -NR A}C(-O)-, -C(-S)NR^A, -NR^AC(-S)-, -SO₂NR^A-, -NR^ASO₂-, -OC(-O)NR^{A-, -NRA}C(-O)O-, or -NR^A- wherein R^A is hydrogen or C₁-C₆ alkyl. p, r and s are independently 0 or 1. R₁ represents a radical -(Alk³)_a-(Y)b-(Alk⁴)_d-B wherein a, b and d are independently 0 or 1; Alk³ and Alk⁴ are optionally substituted divalent C,-C3 alkylene radicals; Y represents a monocyclic divalent carbocyclic or heterocyclic radical having from 5 to 8 ring atoms, -O-, -S-, or -NR^A- wherein R^A is hydrogen or C₁-C₆ alkyl; B represents hydrogen or halo, or an optionally substituted monocyclic carbocyclic or heterocyclic ring having from 5 to 8 ring atoms, or in the case where Y is -NR^A- and b is 1, then R^A and the radical -(Alk⁴)_d-B taken together with the nitrogen to which they are attached may form an optionally substituted heterocyclic ring. R represents hydrogen, halo, C₁-C₆ alkyl, C1-C₆ alkoxy, C₁-C₆ alkylthio, phenyl, benzyl, cycloalkyl with 3 to 6 ring atoms, or a monocyclic heterocyclic group having 5 or 6 ring atoms.