LOW-TOXICITY, LONG-CIRCULATING CHIMERAS OF HUMAN INTERFERON- ALPHA ANALOGS AND INTERFERON TAU

摘要

Interferon-alpha (IFNa) analog proteins modified by chemical attachment of at least one hydrophilic polymer moiety, such as polyethylene glycol chain, are described. In one embodiment, the IFNa analog protein has an amino acid sequence that differs from a native human IFNa interferon-alpha by one or more amino acid residues in the N-terminal region, comprised of between about residues 1-27, inclusive, by one or more substitutions selected based on the amino acid residue at the corresponding position of a mature interferon-tau (IFNt) protein. Methods of treating viral diseases and other disorders with the polymer- modified IFNa analog protein are also described.