Methods of amination

摘要

A method of synthesizing a compound of formula I: comprising the step of reacting a moiety of formula II: with a moiety of formula III: in compressed carbon dioxide in the presence of a transition metal catalyst and a base, wherein L is a labile leaving group; R^N1 is optionally substituted C_5-20 aryl; R^N2 is selected from optionally substituted C_5-20aryl, optionally substituted C_3-20 heterocyclyl, optionally substituted C_3-7 alkyl, and optionally substituted sulfonyl; R^N3 is selected from H and optionally substituted C_1-7 alkyl, C_3-20 heterocyclyl and C_5-20 aryl; or R^N2 and R^N3 together with the nitrogen atom to which they are attached form optionally substituted nitrogen-containing C_3-20 heterocylyl or C_5-20 heteroaryl; and R¹ R² and R³ are independently selected from optionally substituted C_1-7 alkyl, C_5-20 aryl, C_3-20 heterocyclyl, hydroxy, halo, amino and C_1-7 alkoxy, or two of R¹, R² and R³, together with the silicon atom to which they are attached, may form a silicon containing C_5-7 heterocyclyl group.