发明名称 |
Screening of anti-viral drugs and pharmaceuticals composition containing thiazolidinone derivatives |
摘要 |
The present invention relates to a method of screening for small organic molecules that directly inhibit the interaction of glycosaminoglycans (GAGs) with GAG-binding viral proteins (GBVPs), which comprises contacting a GAG with an GBVP in the presence of at least one candidate compound; and measuring the amount of the GAG bound to the GBVP or the amount of the GBVP bound to the GAG, wherein a significant decrease in GAG-GBVP binding as compared to GAG-GBVP binding in the absence of the candidate compound, identifies said compound as inhibitor of the GAG-GBVP interaction. The invention further provides pharmaceutical compositions comprising certain 2-thioxo-thiazolidinone derivatives, particularly useful against virus infections.
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申请公布号 |
US2007179137(A1) |
申请公布日期 |
2007.08.02 |
申请号 |
US20050594080 |
申请日期 |
2005.03.24 |
申请人 |
RIMONYX PHARMACEUTICALS LTD. |
发明人 |
GREGOR PAUL;HARRIS NICHOLAS;ZHUK REGINA |
分类号 |
A61K31/5377;A61K31/427;A61K31/519;C07D417/02;C07D487/04;C12Q1/70 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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