发明名称 |
THERAPEUTIC USES OF ARTIFICIAL NANOSTRUCTURES |
摘要 |
The present invention provides a method for controlling the fate of mammalian cells or microorganisms by the enzymatic formation of intracellular nanostructures. Enzymatic reactions trigger the intracellular self-assembly to convert a proper precursor into another molecule or nanoobject that will aggregate inside cells or inside or between tissues or organs. Further, this invention provides a method for making artificial nanostructures inside or between tissues or organs, by injecting a proper designed precursor into tissues or organs, and enzymatic reaction converting the precursor to a hydrogelator to form artificial nanostructures and inducing hydrogelation and at the state of a disease, another enzyme converts the hydrogelator back to precursor to induce gel-to-sol transition to release a drug. The present invention can be applied to treat diseases caused by the malfunction of cells, infection caused by microorganisms and provides a novel route for controlled drug releases, formation of new therapeutic agents, and in-situ formation of hydrogel to treat degenerative diseases such as osteoarthritis.
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申请公布号 |
WO2007018607(A3) |
申请公布日期 |
2007.08.02 |
申请号 |
WO2006US08333 |
申请日期 |
2006.03.06 |
申请人 |
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY;XU, BING;YANG, ZHIMOU;XU, KEMING |
发明人 |
XU, BING;YANG, ZHIMOU;XU, KEMING |
分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
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