NOVEL POLYMORPH E OF OLANZAPINE AND PREPARATION OF ANHYDROUS NON-SOLVATED CRYSTALINE POLYMORPHIC FORM I OF 2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO[2,3-B][1,5]BENZODIAZEPINE (OLANSAPINE FORM I) FROM THE POLYMORPHIC OLANZAPINE FORM E

摘要

The invention provides an Olanzapine pseudopolymoph Form E. The invention provides methods of preparing polymorphic Olanzapine Form E employing rapid crystallization and seeding. The invention provides methods of preparing anhydrous Olanzapine Form I from the Olanzapine Form E by step-wise drying.