METHOD FOR IDENTIFICATION AND MONITORING OF EPIGENETIC MODIFICATIONS
摘要
The present invention provides novel methods for identifying and monitoring epigenetic modifications, such as imprinted genes, using microarray based technology. Specifically, the invention detects imprinted genes by the presence of overlapping closed and open chromatin markers. The invention also discloses a method for detecting the loss of imprinting on a genome-wide scale, which is indicative of a variety of medical conditions. Diagnostic assays and chromatin structure markers for identifying gene imprinting and loss thereof are also disclosed.
申请公布号
WO2007070560(A9)
申请公布日期
2007.08.02
申请号
WO2006US47513
申请日期
2006.12.13
申请人
NIMBLEGEN SYSTEMS, INC.;BJORNSSON, HANS, T.;GREEN, ROLAND, D.;FEINBERG, ANDREW, P.