The present invention is directed to compositions comprising a nanoparticulate clopidogrel, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate clopidogrel particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the prevention and treatment of pathologies induced by platelet aggregation. The clopidogrel particles may also be formulated as a controlled release polymeric coating or matrix drug delivery system.
申请公布号
WO2007086914(A2)
申请公布日期
2007.08.02
申请号
WO2006US17941
申请日期
2006.05.09
申请人
ELAN PHARMA INTERNATIONAL, LIMITED;LIVERSIDGE, GARY, G.;JENKINS, SCOTT