发明名称 Coumarin derivatives, process for their production and use thereof
摘要 Compounds represented by the general formula [I]: wherein R<SUP>1 </SUP>and R<SUP>2 </SUP>are each hydrogen, halogen, an optionally substituted linear hydrocarbon group, or hydroxyl which may be substituted with an optionally substituted liner hydrocarbon group, or R<SUP>1 </SUP>and R<SUP>2 </SUP>together with the carbon atoms adjacent thereto may form an optionally substituted cyclic hydrocarbon or a dihydrofuran ring which may have an oxo group; ring A is a benzene ring which may be further substituted; ring B is an aromatic ring which may be substituted; X is a bond or a spacer whose main chain has 1 to 6 atoms; Y is carboxyl which may be esterified, carbamoyl which may be substituted, cyano, or an optionally substituted heterocyclic group bearing a hydrogen atom capable of being deprotonated, or salts thereof, which are useful as lipid-rich plaque regressing agents and/or ACAT inhibitors.
申请公布号 US2007179154(A1) 申请公布日期 2007.08.02
申请号 US20070728550 申请日期 2007.03.26
申请人 TAKEDA PHARMACEUTICAL COMPANY LIMITED 发明人 TERASHITA ZEN-ICHI;NAKAMURA MASAHIRA;MARUI SHOGO;OGINO MASAKI
分类号 A61K31/496;A61K31/37;A61P3/06;A61P9/00;A61P9/10;A61P25/28;A61P43/00;C07D209/94;C07D261/14;C07D271/10;C07D277/42;C07D311/12;C07D333/36;C07D405/02;C07D405/10 主分类号 A61K31/496
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