PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES

摘要

Processes for the production of a 32-deoxorapamycin from a 32-iodo- or 32- hydroxyrapamycin, wherein the hydroxy group is substituted by the residue of an arylthionocarbonate or an arylthiocarbamate, in the presence of tris(trimethylsilyl)-silan and a.a'-azo-isobutyronitril in organic solvent; and 32-deoxorapamycin in the form of a crystalline solvate.