ANTI-CANCER AGENT LOADED HYDROPHOBIC BILE ACID CONJUGATED HYDROPHILIC CHITOSAN OLIGOSACCHARIDE NANOPARTICLES AND PREPARATION METHOD THEREOF

摘要

Disclosed herein are hydrophobic bile acid- conjugated hydrophilic chitosan oligosaccharide nanoparticles with anticancer agent loaded therein and a method for preparing the same. The hydrophobic bile acid- conjugated hydrophilic chitosan oligosaccharide nanoparticles form self-aggregates in aqueous phases. With a high load of anticancer agents, the hydrophobic bile acid-conjugated chitosan oligosaccharide nanoparticles with anticancer agents loaded therein exhibit excellent cytotoxicity against cancer cells. Also, the nanoparticles release the anticancer agent in a sustained manner therefrom, thereby exhibiting anticancer activity for a prolong period of time. Therefore, the nanoparticles are very useful in cancer chemotherapy.